AβPP transgenic mouse lines differ in the types and amounts of Aβ that they generate and in their spatiotemporal patterns of expression of Aβ asse mblies, providing a toolkit to study Aβ amyloidosis and the influence of Aβ aggregation on brain function. Ībstract: There exist several dozen lines of transgenic mice that express human amyloid-β protein precursor (AβPP) with Alzheimer’s disease (AD)-linked mutations. Bud Grossman Center for Memory Research and Care, 5-184 Wallin Medical Biosciences Building, 2101 6th Street SE, Minneapolis, MN 55455, USA. | Department of Cellular and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USAĬorrespondence to: Kathleen R. | Department of Neuroscience, University of Florida, Gainesville, FL, USA | GRECC, VA Medical Center, Minneapolis, MN, USA | Department of Neuroscience, University of Minnesota, Minneapolis, MN, USA | UMN Academic Health Center Biological Materials Procurement Network, University of Minnesota, Minneapolis, MN, USA | Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA Bud Grossman Center for Memory Research and Care, University of Minnesota, Minneapolis, MN, USA a b *Īffiliations: Department of Neurology, University of Minnesota, Minneapolis, MN, USA
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